EWSR1 Antibody
CATALOG NUMBER: 57-829- Clonality: Polyclonal
- Tested Applications: IF, WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Mouse
- IMMUNOGEN: This EWSR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 623-652 amino acids from the C-terminal region of human EWSR1.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: IF, WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
For IF starting dilution is: 1:10~50 - PREDICTED MOLECULAR WEIGHT: 68 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: EWSR1
- ADDITIONAL NAMES: RNA-binding protein EWS, EWS oncogene, Ewing sarcoma breakpoint region 1 protein, EWSR1, EWS
- Protein Accession Number: Q01844
- PROTEIN GI NUMBER: 544261
- NCBI GENE ID NUMBER: 2130
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- This gene encodes a multifunctional protein that isinvolved in various cellular processes, including gene expression,cell signaling, and RNA processing and transport. The proteinincludes an N-terminal transcriptional activation domain and aC-terminal RNA-binding domain. Chromosomal translocations betweenthis gene and various genes encoding transcription factors resultin the production of chimeric proteins that are involved intumorigenesis. These chimeric proteins usually consist of theN-terminal transcriptional activation domain of this protein fusedto the C-terminal DNA-binding domain of the transcription factorprotein. Mutations in this gene, specifically a t(11;22)(q24;q12)translocation, are known to cause Ewing sarcoma as well asneuroectodermal and various other tumors. Alternative splicing ofthis gene results in multiple transcript variants. Relatedpseudogenes have been identified on chromosomes 1 and 14. [providedby RefSeq].
- 1: Lagirand-Cantaloube, J., et al. Biochem. Biophys. Res. Commun. 399(4):705-710(2010)
- 2: Kumagai, A., et al. Am. J. Clin. Pathol. 134(2):323-331(2010)
- 3: Aryee, D.N., et al. Cancer Res. 70(10):4015-4023(2010)
- 4: Riggi, N., et al. Genes Dev. 24(9):916-932(2010)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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$35 Dry Ice Shipment fee may be required on some items.
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