- Trial Size
EMX2 Antibody
CATALOG NUMBER: 4099- Clonality: Polyclonal
- Tested Applications: ELISA, IHC-P
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 0.02 mg | 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Mouse: (94%), Bovine: (94%)
- IMMUNOGEN: EMX2 antibody was raised against an 16 amino acid synthetic peptide near the amino terminus of human EMX2.
The immunogen is located within the first 50 amino acids of EMX2. - CONJUGATE: Unconjugated
- TESTED APPLICATIONS: ELISA, IHC-P
- APPLICATION NOTE: EMX2 antibody can be used for detection of EMX2 by immunohistochemistry at 5 μg/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested. - SPECIFICITY: At least two isoforms of EMX2 are known to exist; this antibody will detect both isoforms. EMX2 antibody is predicted to not cross-react with EMX1.
- POSITIVE CONTROL 1: Cat. No. 10-635 - Human Prostate Tissue Slide
- PREDICTED MOLECULAR WEIGHT: 28 kDa
Properties
- PURIFICATION: EMX2 Antibody is affinity chromatography purified via peptide column.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: EMX2 Antibody is supplied in PBS containing 0.02% sodium azide.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: EMX2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: EMX2
- ADDITIONAL NAMES: EMX2 Antibody: Homeobox protein EMX2, Empty spiracles homolog 2
- Protein Accession Number: Q04743
- PROTEIN GI NUMBER: 19862512
- NCBI GENE ID NUMBER: 2018
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- EMX2 Antibody: EMX2, like its closely related homolog EMX1, is a homeobox transcription factor involved in specifying cell fates in the developing central nervous system and participates in the development of olfactory neurons. EMX2 is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10.
- 1: Bishop KM, Garel S, Nakagawa Y, et al. EMX1 and Emx2 cooperate to regulate cortical size, lamination, neuronal differentiation, development of cortical efferents, and thalamocortical pathfinding. J. Comp. Neurol. 2003; 457:345-60.
- 2: Lichtneckert R, Nobs L, Reichert H. Empty spiracles is required for the development of olfactory projection neuron circuitry in Drosophila. Development 2008; 135:2415-24.
- 3: Gulisano M, et al. EMX2 and Emx2 show different patterns of expression during proliferation and differentiation of the developing cerebral cortex in the mouse. Eur. J. Neurosci. 1996; 8:1037-50.
- 4: Nedelec S, Foucher I, Brunet I, et al. Emx2 homeodomain transcription factor interacts with eukaryotic translation initiation factor 4E (eIF4E) in the axons of olfactory sensory neurons. Proc. Natl. Acad. Sci. USA 2004; 101:10815-20.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
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