EIF2AK3 Antibody
CATALOG NUMBER: 57-811- Clonality: Polyclonal
- Tested Applications: IHC-P, WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- IMMUNOGEN: This EIF2AK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 73-102 amino acids from the N-terminal region of human EIF2AK3.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: IHC-P, WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50 - PREDICTED MOLECULAR WEIGHT: 125 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: EIF2AK3
- ADDITIONAL NAMES: Eukaryotic translation initiation factor 2-alpha kinase 3, PRKR-like endoplasmic reticulum kinase, Pancreatic eIF2-alpha kinase, HsPEK, EIF2AK3, PEK, PERK
- Protein Accession Number: Q9NZJ5
- PROTEIN GI NUMBER: 296439367
- NCBI GENE ID NUMBER: 9451
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- The protein encoded by this gene phosphorylates the alphasubunit of eukaryotic translation-initiation factor 2 (EIF2),leading to its inactivation, and thus to a rapid reduction oftranslational initiation and repression of global proteinsynthesis. It is a type I membrane protein located in theendoplasmic reticulum (ER), where it is induced by ER stress causedby malfolded proteins. Mutations in this gene are associated withWolcott-Rallison syndrome.
- 1: Xu, H., et al. Toxicology 277 (1-3), 1-5 (2010) :
- 2: Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- 3: Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- 4: Kim, K.W., et al. Oncogene 29(22):3241-3251(2010)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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$35 Dry Ice Shipment fee may be required on some items.
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