EGFR (phospho Tyr1110) Antibody
CATALOG NUMBER: 79-485- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Conjugate: Unconjugated
- Size: 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Rat
- IMMUNOGEN: EGFR (phospho-Tyr1110) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1110 (P-V-Y (p) -H-N) derived from Human EGFR.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: Western Blot: 1:500~1:1000
- SPECIFICITY: This antibody detects endogenous level of EGFR only when phosphorylated at tyrosine 1110.
- PREDICTED MOLECULAR WEIGHT: 175 kDa
Properties
- PURIFICATION: Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
- CLONALITY: Polyclonal
- PHYSICAL STATE: Liquid
- BUFFER: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: Store antibody at -20°C for up to one year.
Additional Info
- NCBI OFFICIAL SYMBOL: EGFR
- ADDITIONAL NAMES: ERBB, HER1, mENA, ERBB1, PIG61, A4, AD1, Receptor protein-tyrosine kinase ErbB-1, kinase EGFR
- Protein Accession Number: NP_005219.2
- PROTEIN GI NUMBER: 29725609
- NCBI GENE ID NUMBER: 1956
Background
- Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.
- 1: Kaisa Erjala, et, al. (2006) Clin. Cancer Res Jul 2006; 12: 4103 - 4111. Judit Anido, et, al. (2003) Clin. Cancer Res ; 9: 1274. Julian Andreev, et, al. (2001) J. Biol. Chem ; 276: 20130 - 20135. Suil Kim, et, al. (2002) Am J Physiol Lung Cell Mol Physiol, ; 283: 67.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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