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Dynamin-1 Antibody [3G4B6]
CATALOG NUMBER: 32-146- Clonality: Monoclonal
- Tested Applications: E, IHC, WB
- Host Species: Mouse
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 0.1 mL
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- HOST SPECIES: Mouse
- SPECIES REACTIVITY: Human
- IMMUNOGEN: Ni-NTA purified truncated recombinant Dynamin-1 expressed in E. Coli strain BL21 (DE3).
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: E, IHC, WB
- APPLICATION NOTE: Western Blot:1:500 - 1:2,000
IHC(P):1:500 - 1:2,000
IHC(F):1:500 - 1:2,000
ELISA:Propose dilution 1:10,000
Determining optimal working dilutions by titration test.
Properties
- CLONALITY: Monoclonal
- ISOTYPE: IgG2a
- BUFFER: Ascitic fluid containing 0.03% sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Dynamin-1 monoclonal antibody can be stored at -20°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: DNM1
- ADDITIONAL NAMES: DNMDNM
- Protein Accession Number: Q05193
- PROTEIN GI NUMBER: 172046078
- NCBI GENE ID NUMBER: 1759
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- Dynamin-1 (Dyn1), with 864-amino acid protein (about 95 kDa), belongs to the dynamin family. Dynamin-1 (neuron-specific), dynamin-2 (ubiquitously expressed), and dynamin-3 (expressed only in the testis, brain, and lung), constitute the dynamin family. Members of the dynamin family are GPTase, microtubule-associated proteins which are involved in endocytosis, synaptic transmission and neurogenesis. Dynamin-1 is phosphorylated in nerve terminals exclusively in the cytosolic compartment and in vitro by protein kinase C. Dynamin-1 is a large GTPase enzyme required in membrane constriction and fission during multiple forms of endocytosis. Dynamin-1 is also a key molecule required for the recycling of synaptic vesicles in neurons, and it has been known that dynamin-1 gene expression is induced during neuronal differentiation.
- 1: Annie Quan and Phillip J. Robinson. Methods Enzymol. 2005; 404:556-69.
- 2: Jiyun Yoo, Moon-Jin Jeong, Byoung-Mog Kwon. J. Biol. Chem., Mar 2002; 277: 11904 – 11909.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
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