DAAM1-T361 Antibody
CATALOG NUMBER: 61-929- Clonality: Polyclonal
- Tested Applications: Flow, IHC-P, WB
- Host Species: Rabbit
- Species Reactivity: Hamster, Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Hamster, Human
- IMMUNOGEN: This DAAM1-T361 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-370 amino acids from the N-terminal region of human DAAM1-T361.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: Flow, IHC-P, WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50 - PREDICTED MOLECULAR WEIGHT: 123 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: DAAM1
- ADDITIONAL NAMES: Disheveled-associated activator of morphogenesis 1, DAAM1, KIAA0666
- Protein Accession Number: Q9Y4D1
- PROTEIN GI NUMBER: 34098767
- NCBI GENE ID NUMBER: 23002
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- Functions of the cell cortex, including motility,adhesion, and cytokinesis, are mediated by the reorganization ofthe actin cytoskeleton and recent evidence suggests a role for theFormin homology (FH) proteins in these processes. The proteinencoded by this gene contains FH domains and belongs to a novel FHprotein subfamily implicated in cell polarity. Wnt/Fz signalingactivates the small GTPase Rho, a key regulator of cytoskeletonarchitecture, to control cell polarity and movement duringdevelopment. Activation requires Dvl-Rho complex formation, anassembly mediated by this gene product, which is thought tofunction as a scaffolding protein. Evidence of alternative splicinghas been observed for this gene but the full-length nature of thesevariants has not been determined.
- 1: Higashi, T., et al. J. Biol. Chem. 283(13):8746-8755(2008)
- 2: Liu, W., et al. Proc. Natl. Acad. Sci. U.S.A. 105(1):210-215(2008)
- 3: Yamashita, M., et al. Genes Cells 12(11):1255-1265(2007)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
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