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Home / Human / Cytokeratin 7 Antibody [CTKN7-1]
Cytokeratin 7 Antibody [CTKN7-1]Cytokeratin 7 Antibody [CTKN7-1]Cytokeratin 7 Antibody [CTKN7-1]
Cytokeratin 7 Antibody [CTKN7-1]
Cytokeratin 7 Antibody [CTKN7-1]
Cytokeratin 7 Antibody [CTKN7-1]

Cytokeratin 7 Antibody [CTKN7-1]

CATALOG NUMBER: 33-945
  • Clonality: Monoclonal
  • Tested Applications: IF, IHC-P, WB
  • Host Species: Mouse
  • Species Reactivity: Human
  • Conjugate: Unconjugated
  • Size: 100 ug

Specifications

  • HOST SPECIES: Mouse
  • SPECIES REACTIVITY: Human
  • IMMUNOGEN: Recombinant full-length human KRT7 protein was used as the immunogen for the Cytokeratin 7 antibody.
  • CONJUGATE: Unconjugated
  • TESTED APPLICATIONS: IF, IHC-P, WB
  • APPLICATION NOTE: Immunofluorescence: 0.5-1 ug/ml
    Immunohistochemistry (FFPE): 0.5-1 ug/ml for 30 min at RT (1)
    Prediluted format : incubate for 30 min at RT (2)
    Optimal dilution of the Cytokeratin 7 antibody should be determined by the researcher.

    1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes
    2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Properties

  • PURIFICATION: Protein G affinity chromatography
  • CLONALITY: Monoclonal
  • ISOTYPE: IgG1
  • PHYSICAL STATE: Liquid
  • BUFFER: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
  • CONCENTRATION: 0.2 mg/mL
  • STORAGE CONDITIONS: Aliquot and Store at 2-8°C. Avoid freez-thaw cycles.

Additional Info

  • NCBI OFFICIAL SYMBOL: KRT7
  • ADDITIONAL NAMES: Keratin, type II cytoskeletal 7, Cytokeratin-7, CK-7, Keratin-7, K7, Sarcolectin, Type-II keratin Kb7, KRT7, SCL
  • NCBI GENE ID NUMBER: 3855
  • USER NOTE: Optimal dilutions for each application to be determined by the researcher

Background

  • Cytokeratin-7 (CK7) is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. CK7 is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. It is found in simple glandular epithelia, and in transitional epithelium. Epithelial cells of the lung and breast both contain CK7, but some other glandular epithelia, such as those of the colon and prostate, do not. Because the protein is found in both healthy and neoplastic cells, antibodies to CK7 can be used in immunohistochemistry to distinguish ovarian and transitional cell carcinomas from colonic and prostate cancers, respectively. It is commonly used together with CK20 when making such diagnoses. [Wiki]

Disclaimer

  • FOR RESEARCH USE ONLY
    For additional information, visit ProSci's Terms & Conditions Page.
  • Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER: 33-945

  • Size: 100 ug
  • List Price: $555.00
Datasheet
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