- Trial Size
CPEB1 Antibody
CATALOG NUMBER: 4687- Clonality: Polyclonal
- Tested Applications: ELISA, WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Conjugate: Unconjugated
- Size: 0.02 mg | 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Rat
- IMMUNOGEN: CPEB1 antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human CPEB1.
The immunogen is located within amino acids 50 - 100 of CPEB1. - CONJUGATE: Unconjugated
- TESTED APPLICATIONS: ELISA, WB
- APPLICATION NOTE: CPEB1 antibody can be used for detection of CPEB1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested. - POSITIVE CONTROL 1: Cat. No. 1463 - Rat Brain Tissue Lysate
Properties
- PURIFICATION: CPEB1 Antibody is affinity chromatography purified via peptide column.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: CPEB1 Antibody is supplied in PBS containing 0.02% sodium azide.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: CPEB1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: CPEB1
- ADDITIONAL NAMES: CPEB1 Antibody: CEBP, CPEB, CPEB-1, CPE-BP1, hCPEB-1, Cytoplasmic polyadenylation element-binding protein 1
- Protein Accession Number: Q9BZB8
- PROTEIN GI NUMBER: 74762720
- NCBI GENE ID NUMBER: 64506
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- CPEB1 Antibody: CPEB1 is an RNA binding protein that contains an RNA-recognition motif and a zinc finger-containing region found in a wide range of vertebrates and invertebrates. CPEB1 forms the nucleus of a complex of factors that regulate poly(A) elongation and promotes polyadenylation-induced translation. CPEB1 mediates many diverse biological processes such as germ cell development, cell division and senescence, and synaptic plasticity. Recently, it was discovered that CPEB1 is involved in beta-catenin mRNA translation and cell migration in astrocytes as well as regulating hypoxia-inducible factor (HIF)-1 expression, demonstrating the wide range of processes in which CPEB1 plays a role. At least four isoforms of CPEB1 are known to exist.
- 1: Richter JD. CPEB: a life in translation. Trends in Biochem. Sci.2007; 32:179-85.
- 2: Jones KJ, Korb E, Kundel MA, et al. CPEB1 regulates beta-catenin mRNA translation and cell migration in astrocytes. Glia2008; 56:1401-13.
- 3: Hagele S, Kuhn U, Boning M, et al. Cytoplasmic polyadenylation element binding protein (CPEB)1 and 2 bind to the HIF-1alpha mRNA 3'UTR and modulate HIF-1 alpha protein expression. Biochem. J.2008; epub.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
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