Connexin Antibody
CATALOG NUMBER: 50-200- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Chicken, Dog, Frog, Human, Mouse, Rat, Sheep, Zebrafish
- Conjugate: Unconjugated
- Size: 0.1 mL
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Chicken, Dog, Frog, Human, Mouse, Rat, Sheep, Zebrafish
- IMMUNOGEN: Peptide corresponding to amino acid residues from the C-terminal region of rat connexin43.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: The antibody has been directly tested for reactivity in Western blots in rat tissues. It is anticipated that the antibody will also work with chicken, dog, finch, human, mouse, non-human primate, sheep, Xenopus and zebra fish tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
- PREDICTED MOLECULAR WEIGHT: 43
Properties
- PURIFICATION: Affinity Purified
- CLONALITY: Polyclonal
- PHYSICAL STATE: Liquid
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Connexin antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
Additional Info
- NCBI OFFICIAL SYMBOL: Gja1
- Protein Accession Number: P08050
- PROTEIN GI NUMBER: 117708
- NCBI GENE ID NUMBER: 24392
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy (Aronica et al., 2001). Connexin43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of connexin43 is known to be regulated by phosphorylation at er368 by protein kinase C (Yogo et al., 2002; Bao et al., 2004a). Phosphorylation of Ser368 by PKC induces a conformational change of connexin43 that results in a decrease in gap junction permeability (Bao et al., 2004b).
- 1: Aronica E, Gorter JA, Jansen GH, Leenstra S, Yankaya B, Troost D (2001) Expression of connexin 43 and connexin 32 gap-junction proteins in epilepsy-associated brain tumors and in the perilesional epileptic cortex. Acta Neuropathol (Berl) 101:449-459.
- 2: Bao X, Altenberg GA, Reuss L (2004a) Mechanism of regulation of the gap junction protein connexin 43 by protein kinase C-mediated phosphorylation. Am J Physiol Cell Physiol 286:C647-C654.
- 3: Bao X, Reuss L, Altenberg GA (2004b) Regulation of purified and reconstituted connexin 43 hemichannels by protein kinase C-mediated phosphorylation of Serine 368. J Biol Chem 279:20058-20066.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: This product is for research use only.
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