Connexin 50 Antibody
CATALOG NUMBER: 58-184- Clonality: Polyclonal
- Tested Applications: IHC-P, WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Chicken
- IMMUNOGEN: This Connexin 50 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 402-433 amino acids from the C-terminal region of human Connexin 50.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: IHC-P, WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100 - PREDICTED MOLECULAR WEIGHT: 48 kDa
Properties
- PURIFICATION: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: GJA8
- ADDITIONAL NAMES: Gap junction alpha-8 protein, Connexin-50, Cx50, Lens fiber protein MP70, GJA8
- Protein Accession Number: P48165
- PROTEIN GI NUMBER: 13124697
- NCBI GENE ID NUMBER: 2703
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- GJA8 is a an integral membrane protein that belongs to the connexin family, alpha-type (group II) subfamily. One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. This particular connexin only forms junctional channels. GJA8 is expressed in the eye lens, and defects in GJA8 are the cause of zonular pulverulent cataract type 1 (CZP1), a form of autosomal dominant congenital cataract.
- 1: Shiels, A., et al., Am. J. Hum. Genet. 62(3):526-532 (1998). Church, R.L., et al., Curr. Eye Res. 14(10):979-981 (1995). Church, R.L., et al., Curr. Eye Res. 14(3):215-221 (1995).
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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