COCH Antibody
CATALOG NUMBER: 55-789- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Bovine
- IMMUNOGEN: This COCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 492-520 amino acids from the C-terminal region of human COCH.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 59 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: COCH
- ADDITIONAL NAMES: Cochlin, COCH-5B2, COCH, COCH5B2
- Protein Accession Number: O43405
- NCBI GENE ID NUMBER: 1690
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- The protein encoded by this gene is highly conserved inhuman, mouse, and chicken, showing 94% and 79% amino acid identityof human to mouse and chicken sequences, respectively.Hybridization to this gene was detected in spindle-shaped cellslocated along nerve fibers between the auditory ganglion andsensory epithelium. These cells accompany neurites at the habenulaperforata, the opening through which neurites extend to innervatehair cells. This and the pattern of expression of this gene inchicken inner ear paralleled the histologic findings of acidophilicdeposits, consistent with mucopolysaccharide ground substance, intemporal bones from DFNA9 (autosomal dominant nonsyndromicsensorineural deafness 9) patients. Mutations that cause DFNA9 havebeen reported in this gene. Alternative splicing results inmultiple transcript variants encoding the same protein. Additionalsplice variants encoding distinct isoforms have been described buttheir biological validities have not been demonstrated. [providedby RefSeq].
- 1: Ikezono, T., et al. Acta Otolaryngol. 130(8):881-887(2010)
- 2: Yao, J., et al. J. Biol. Chem. 285(20):14909-14919(2010)
- 3: Baek, J.I., et al. Clin. Genet. 77(4):399-403(2010)
- 4: Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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$35 Dry Ice Shipment fee may be required on some items.
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