CLEC12A / MICL / CLL-1 Recombinant Protein
CATALOG NUMBER: 11-205- Tested Applications: WB
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- SPECIES: Cynomolgus monkey
- SOURCE SPECIES: HEK293 cells
- RECOMBINANT PROTEIN SEQUENCE: His 65 - Ala 265
- FUSION TAG: His Tag
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 25.5 kDa. The protein migrates as 35-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- PREDICTED MOLECULAR WEIGHT: 25.5 kDa
Properties
- PURITY: >90% as determined by SDS-PAGE.
- PHYSICAL STATE: Lyophilized
- BUFFER: PBS, pH7.4
- STORAGE CONDITIONS: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Additional Info
- ADDITIONAL NAMES: CLEC12A,MICL,CLL-1,CLL1,DCAL2,DCAL-2,CD371
Background
- CLEC12A (C-type lectin domain family 12 member A) is also known as CLL1, DCAL2, MICL. Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. Evidence of distinct disease propagating stem cells in myelodysplastic syndrome (MDS) has emerged in recent years. The role of CLEC12A in MDS, however, remains to be elucidated. Furthermore, CLEC12A has been proposed as a promising marker of leukaemic stem cells in AML.
- 1: Toft-Petersen M, et al. 2016. Br J Haematol. 175(3):393-401.
- 2: Neumann K, et al. 2014. Immunity. 40(3):389-99.
- 3: Chen CH, et al. 2006. Blood. 107(4):1459-67.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
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