- HOST SPECIES: Rat
- SPECIES REACTIVITY: Mouse, Pig
- IMMUNOGEN: Mouse NS-1 cells
- CONJUGATE: PE
- TESTED APPLICATIONS: Flow
- APPLICATION NOTE: CD54 Antibody [YN1/1.7.4] for use in flow cytometry assays.
- SPECIFICITY: CD54
- CLONALITY: Monoclonal
- ISOTYPE: IgG2b
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS/NaN3 and a stabilizing agent
- CONCENTRATION: 0.1 mg/mL
- STORAGE CONDITIONS: Store vial at 2-8°C
- NCBI OFFICIAL SYMBOL: Icam1
- ADDITIONAL NAMES: ICAM-1, Ly-47
- Protein Accession Number: P13597
- NCBI GENE ID NUMBER: 15894
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
- CD54, a member of the immunoglobulin superfamily of cell surface receptors and also known as Intercellular Adhesion Molecule-1 (ICAM-1), is a type I transmembrane glycoprotein that mediates important cell/cell interactions. CD54 is expressed on endothelial cells, dendritic cells, keratinocytes, and lymphocytes. Its expression is upregulated by inflammatory mediators such as IFN gamma, IL-1, TNF-alpha, lipopolysaccharide, and phorbol esters. Endothelial CD54 contributes to the extravasation of leukocytes from blood vessels, particularly in areas of inflammation. CD54 on antigen-presenting cells contributes to antigen-specific T-cell activation, presumably by enhancing interactions between T cell and antigen-presenting cells. These adhesion reactions are mediated via the binding of CD54 to its major ligands, LFA-1 and Mac-1.
- FOR RESEARCH USE ONLY
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- Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
CATALOG NUMBER: 98-815
- Size: 0.1 mg
- List Price: $350.00
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