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CD28 Antibody [AV7] (PE)
CD28 Antibody [AV7] (PE)

CD28 Antibody [AV7] (PE)

CATALOG NUMBER: 99-239
  • Clonality: Monoclonal
  • Tested Applications: Flow
  • Host Species: Mouse
  • Species Reactivity: Chicken, Turkey
  • Conjugate: PE
  • Size: 0.1 mg

Specifications

  • HOST SPECIES: Mouse
  • SPECIES REACTIVITY: Chicken, Turkey
  • IMMUNOGEN: Chicken peripheral blood lymphocytes
  • CONJUGATE: PE
  • TESTED APPLICATIONS: Flow
  • APPLICATION NOTE: CD28 Antibody [AV7] for use in flow cytometry assays.
  • SPECIFICITY: CD28

Properties

  • CLONALITY: Monoclonal
  • ISOTYPE: IgG1
  • PHYSICAL STATE: Liquid
  • BUFFER: Supplied in PBS/NaN3 and a stabilizing agent
  • CONCENTRATION: 0.1 mg/mL
  • STORAGE CONDITIONS: Store vial at 2-8°C

Additional Info

  • NCBI OFFICIAL SYMBOL: CD28
  • Protein Accession Number: P31043
  • NCBI GENE ID NUMBER: 396249
  • USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background

  • Chicken CD28 antigen is a type I transmembrane monomeric glycoprotein which does not contain the cysteine residues that form disulfide-linked covalent homodimers found in the mammalian counterpart. This may reduce the avidity of binding to individual ligand molecules expected to be present on antigen presenting cells. Peripheral gammadelta+ T cells are CD28 negative. Monoclonal antibodies against CD28 have a costimulatory effect on T cells stimulated by phorbol myristate acetate (PMA), concanavalin A, or monoclonal antibodies against the avian T cell receptor (TCR). Both Vbeta1- and Vbeta2-expressing cells respond equally well to stimulation with anti-CD28 in combination with PMA. These responses are resistant to cyclosporin A but inhibited by herbimycin A suggesting that CD28 employs a signaling pathway at least partly distinct from that triggered by TCR/CD3. The monoclonal antibody AV7 also reacts with turkey CD28 as demonstrated by flow cytometry.

Disclaimer

  • FOR RESEARCH USE ONLY
    For additional information, visit ProSci's Terms & Conditions Page.
  • Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER: 99-239

  • Size: 0.1 mg
  • List Price: $380.00
Datasheet
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