![CD27 Antibody [O323] (APC-Cy7)](https://www.prosci-inc.com/wp-content/uploads/2021/11/76-629.jpg){kind=small}
CD27 Antibody [O323] (APC-Cy7)
CATALOG NUMBER: 76-629- Clonality: Monoclonal
- Tested Applications: Flow
- Host Species: Mouse
- Species Reactivity: Human
- Conjugate: APC-Cy7
- Size: 25 tests
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- HOST SPECIES: Mouse
- SPECIES REACTIVITY: Human
- CONJUGATE: APC-Cy7
- TESTED APPLICATIONS: Flow
- SPECIFICITY: The O323 monoclonal antibody specifically binds to the human CD27, which is a lymphocyte-specific member of the TNF/NGF-R family, expressed on a subset of human thymocytes and the majority of the mature T cells.
Properties
- PURIFICATION: The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
- CLONALITY: Monoclonal
- ISOTYPE: Mouse IgG1, kappa
- PHYSICAL STATE: liquid
- BUFFER: Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Additional Info
- NCBI OFFICIAL SYMBOL: CD27
- ADDITIONAL NAMES: T14, S152, Tp55, TNFRSF7, S152. LPFS2, CD27
- NCBI GENE ID NUMBER: 939
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- The O323 monoclonal antibody specifically binds to the human CD27, which is a lymphocyte-specific member of the TNF/NGF-R family, expressed on a subset of human thymocytes and the majority of the mature T cells. CD27 is upregulated by T lymphocytes stimulation, and binds to CD70, enhancing the interaction between T and B lymphocytes. CD27 is a marker of memory B cells.
- 1: Hendriks, J., Xiao, Y., Borst, J. (2003). CD27 promotes survival of activated T cells and complements CD28 in generation and establishment of the effector T cell pool.The Journal of experimental medicine,198(9), 1369-1380.
- 2: Sakanishi, T., Yagita, H. (2010). Anti-tumor effects of depleting and non-depleting anti-CD27 monoclonal antibodies in immune-competent mice.Biochemical and biophysical research communications,393(4), 829-835.
- 3: Gravestein, L. A., Nieland, J. D., Kruisbeek, A. M., Borst, J. (1995). Novel mAbs reveal potent co-stimulatory activity of murine CD27.International immunology,7(4), 551-557.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
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