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CD2 Antibody [RPA-2.10]
CATALOG NUMBER: 76-186- Clonality: Monoclonal
- Tested Applications: Flow, Functional Assays
- Host Species: Mouse
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 0.5 mg
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- HOST SPECIES: Mouse
- SPECIES REACTIVITY: Human
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: Flow, Functional Assays
- SPECIFICITY: The RPA-2.10 monoclonal antibody specifically binds to human CD2, a 50 kDA type I transmembrane glycoprotein.
Properties
- PURIFICATION: The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
- CLONALITY: Monoclonal
- ISOTYPE: Mouse IgG1, kappa
- PHYSICAL STATE: liquid
- BUFFER: Phosphate-buffered aqueous solution, ph7.2.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: The product should be stored undiluted at 4°C . Do not freeze.
Additional Info
- NCBI OFFICIAL SYMBOL: CD2
- ADDITIONAL NAMES: T11, SRBC, LFA-2, CD2
- NCBI GENE ID NUMBER: 914
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- The RPA-2.10 monoclonal antibody specifically binds to human CD2, a 50 kDA type I transmembrane glycoprotein. CD2 is expressed on NK cells, thymocytes, T lymphocytes, and B cell subsets. CD2 is involved in cell-cell adhesion, T cell activation, and T cell signaling. Its ligand is CD58 and it is reported to bind to CD48, CD59, and CD15. The RPA-2.10 antibody is reported to be cross-reactive with pigs and non-human primates..
- 1: Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.
- 2: Hahn, W. C., Burakoff, S. J., Bierer, B. E. (1993). Signal transduction pathways involved in T cell receptor-induced regulation of CD2 avidity for CD58.The Journal of Immunology,150(7), 2607-2619.
- 3: Aversa, G. G., Bishop, G. A., Suranyi, M. G., Hall, B. M. (1987, February). RPA-2.10: an anti-CD2 monoclonal antibody that inhibits alloimmune responses and monitors T cell activation. InTransplantation proceedings(Vol. 19, No. 1 Pt 1, pp. 277-278).
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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$35 Dry Ice Shipment fee may be required on some items.
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