Specifications
- HOST SPECIES: Hamster
- SPECIES REACTIVITY: Mouse
- IMMUNOGEN: Heat-killed Staphylococcus A bacteria coated with mouse CTLA-4/human IgG1 fusion protein
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: Flow, ICC, IHC-Fr, Separation
- APPLICATION NOTE: CD152 Antibody [9H10] for use in flow cytometry, ELISA, blocking, and costimulation assays.
- SPECIFICITY: CD152
Properties
- CLONALITY: Monoclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
- CONCENTRATION: 0.5 mg/mL
- STORAGE CONDITIONS: Store vial at 2-8°C
Additional Info
- NCBI OFFICIAL SYMBOL: Ctla4
- ADDITIONAL NAMES: CTLA-4, cytotoxic T-lymphocyte protein 4
- Protein Accession Number: P09793
- NCBI GENE ID NUMBER: 12477
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- CD152, also known as CTLA-4, is homologous to the costimulatory molecule CD28. Like CD28, the CD152 molecule binds the family of B7 counter-receptors (CD80 and CD86) on antigen-presenting cells. CTLA-4 is not expressed on resting T lymphocytes but is induced 2-3 days following T cell stimulation via the T cell receptor (TCR) complex. Whereas CD28 provides a positive costimulatory signal, CD152 is a negative regulator of T-cell activation, possibly by inhibiting tyrosine kinase signaling through the TCR through its association with tyrosine phosphatases such as SHP-2.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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