CD146 Antibody [P1H12] (PE)
CATALOG NUMBER: 76-886- Clonality: Monoclonal
- Tested Applications: Flow
- Host Species: Mouse
- Species Reactivity: Mouse
- Conjugate: PE
- Size: 25 tests
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- HOST SPECIES: Mouse
- SPECIES REACTIVITY: Mouse
- CONJUGATE: PE
- TESTED APPLICATIONS: Flow
- SPECIFICITY: The P1H12 monoclonal antibody reacts with CD146, 118kDA transmembrane glycoprotein that is also called the melanoma cell adhesion molecule (Mel-CAM), MUC18, Endo-CAM, and S-Endo.
Properties
- PURIFICATION: The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
- CLONALITY: Monoclonal
- ISOTYPE: Mouse IgG1, kappa
- PHYSICAL STATE: liquid
- BUFFER: Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Additional Info
- NCBI OFFICIAL SYMBOL: Mcam
- ADDITIONAL NAMES: CD146, CD149, Muc18, s-endo, AV025631, 1-gicerin, s-gicerin, Mcam
- NCBI GENE ID NUMBER: 84004
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- The P1H12 monoclonal antibody reacts with CD146, 118kDA transmembrane glycoprotein that is also called the melanoma cell adhesion molecule (Mel-CAM), MUC18, Endo-CAM, and S-Endo. It is a prominently glycosylated protein with carbohydrates comprising the majority of its mass and it is expressed on melanoma, stromal, endothelial, and bone marrow fibroblasts. The P1H12 antibody cross reacts with human, mouse, canine, rabbit to the exclusion of rat protein.
- 1: Chen, J. W., Cha, Y. I. N. G., Yuksel, K. U., Gracy, R. W., August, J. T. (1988). Isolation and sequencing of a cDNA clone encoding lysosomal membrane glycoprotein mouse LAMP-1. Sequence similarity to proteins bearing onco-differentiation antigens.Journal of Biological Chemistry,263(18), 8754-8758.
- 2: Grtzkau, A., Smorodchenko, A., Lippert, U., Kirchhof, L., Artuc, M., Henz, B. M. (2004). LAMP1 and LAMP2, but not LAMP3, are reliable markers for activationinduced secretion of human mast cells.Cytometry Part A,61(1), 62-68.
- 3: Sarafian, V., Jadot, M., Foidart, J. M., Letesson, J. J., Van den Brule, F., Castronovo, V., ... Coninck, W. D. (1998). Expression of Lamp1 and Lamp2 and their interactions with galectin3 in human tumor cells.International journal of cancer,75(1), 105-111.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.
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