CD117 Antibody [ACK2] (APC)
CATALOG NUMBER: 76-902- Clonality: Monoclonal
- Tested Applications: Flow
- Host Species: Rat
- Species Reactivity: Mouse
- Conjugate: APC
- Size: 0.1 mg
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- HOST SPECIES: Rat
- SPECIES REACTIVITY: Mouse
- CONJUGATE: APC
- TESTED APPLICATIONS: Flow
- SPECIFICITY: The ACK2 monoclonal antibody specifically reacts with mouse CD117 (c-Kit receptor), a 145 kDa transmembrane tyrosine-kinase receptor encoded by the Kit gene.
Properties
- PURIFICATION: The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
- CLONALITY: Monoclonal
- ISOTYPE: Rat IgG2b, kappa
- PHYSICAL STATE: liquid
- BUFFER: Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Additional Info
- NCBI OFFICIAL SYMBOL: Kit
- ADDITIONAL NAMES: W, Bs, Fdc, Ssm, SCO1, SCO5, SOW3, CD117, c-KIT, Tr-kit, Gsfsco1, Gsfsco5, Gsfsow3, Kit
- NCBI GENE ID NUMBER: 16590
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- The ACK2 monoclonal antibody specifically reacts with mouse CD117 (c-Kit receptor), a 145 kDa transmembrane tyrosine-kinase receptor encoded by the Kit gene. The c-Kit receptor, also known as stem cell factor receptor, is expressed on hematopoietic progenitor cells in adult bone marrow, in progenitors of erythroid and myeloid lineages, and precursors of B and T cells. CD117 enhances the proliferation and the differentiation of the hematopoietic progenitor cells and seems to enhance the development of T cells, as the c-Kit receptor and its ligand are expressed by the thymus.
- 1: Schlossman, S. F. (1995).Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.
- 2: Yarden, Y., Kuang, W. J., Yang-Feng, T., Coussens, L., Munemitsu, S., Dull, T. J., ... Ullrich, A. (1987). Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.The EMBO Journal,6(11), 3341.
- 3: Lerner, N. B., Nocka, K. H., Cole, S. R., Qiu, F. H., Strife, A., Ashman, L. K., Besmer, P. (1991). Monoclonal antibody YB5. B8 identifies the human c-kit protein product.Blood,77(9), 1876-1883.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
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