- KO
CAT Antibody, KO Validated
CATALOG NUMBER: 18-205- Clonality: Polyclonal
- Tested Applications: IP, WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Conjugate: Unconjugated
- Size: 50 uL
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Rat
- IMMUNOGEN: Recombinant fusion protein containing a sequence corresponding to amino acids 1-225 of human CAT (NP_001743.1).
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: IP, WB
- APPLICATION NOTE: WB: 1:1000 - 1:3000
IP: 1:20 - 1:50 - POSITIVE CONTROL 1: HeLa
- PREDICTED MOLECULAR WEIGHT: Observed: 60kDa
Advanced Validation
- VALIDATION: Antibody is Knockout validated.
Properties
- PURIFICATION: Affinity purification
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at -20°C. Avoid freeze / thaw cycles.
Additional Info
- NCBI OFFICIAL SYMBOL: CAT
- ADDITIONAL NAMES: CAT, catalase, HGNC:1516, MGC138422, MGC138424,
- NCBI GENE ID NUMBER: 847
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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