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Home / Apoptosis / Caspase 3 Antibody [D8C2]
Caspase 3 Antibody [D8C2]Caspase 3 Antibody [D8C2]Caspase 3 Antibody [D8C2]Caspase 3 Antibody [D8C2]
Caspase 3 Antibody [D8C2]
Caspase 3 Antibody [D8C2]
Caspase 3 Antibody [D8C2]
Caspase 3 Antibody [D8C2]

Caspase 3 Antibody [D8C2]

CATALOG NUMBER: 13-889
  • Clonality: Monoclonal
  • Tested Applications: IF, IHC, IP, WB
  • Host Species: Rabbit
  • Species Reactivity: Human, Rat
  • Conjugate: Unconjugated

Specifications

  • HOST SPECIES: Rabbit
  • SPECIES REACTIVITY: Human, Rat
  • IMMUNOGEN: Recombinant protein of human Caspase 3
  • CONJUGATE: Unconjugated
  • TESTED APPLICATIONS: IF, IHC, IP, WB
  • APPLICATION NOTE: WB: 1:500 - 1:2000
    IHC: 1:50 - 1:200
    IF: 1:50 - 1:200
    IP: 1:20 - 1:50
  • POSITIVE CONTROL 1: HeLa
  • POSITIVE CONTROL 2: Jurkat
  • POSITIVE CONTROL 3: 293T
  • PREDICTED MOLECULAR WEIGHT: Observed: 32kDa

Properties

  • PURIFICATION: Affinity purification
  • CLONALITY: Monoclonal
  • ISOTYPE: IgG
  • PHYSICAL STATE: Liquid
  • BUFFER: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • CONCENTRATION: batch dependent
  • STORAGE CONDITIONS: Store at -20°C. Avoid freeze / thaw cycles.

Additional Info

  • NCBI OFFICIAL SYMBOL: CASP3
  • ADDITIONAL NAMES: Caspase-3 Antibody: CPP32, SCA-1, CPP32B, CPP32, Caspase-3, Apopain, CASP-3
  • NCBI GENE ID NUMBER: 836
  • USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background

  • This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Disclaimer

  • FOR RESEARCH USE ONLY
    For additional information, visit ProSci's Terms & Conditions Page.
  • Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER: 13-889

    Product Discontinued. Please contact us for alternate product(s).

    Datasheet
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