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CASKIN1 Antibody
CATALOG NUMBER: 6991- Clonality: Polyclonal
- Tested Applications: E, WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 0.02 mg | 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Mouse: (71%), Rat: (71%)
- IMMUNOGEN: CASKIN1 antibody was raised against a 17 amino acid synthetic peptide near the center of human CASKIN1.
The immunogen is located within amino acids 720 - 770 of CASKIN1. - CONJUGATE: Unconjugated
- TESTED APPLICATIONS: E, WB
- APPLICATION NOTE: CASKIN1 antibody can be used for detection of CASKIN1 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. - SPECIFICITY: CASKIN1 antibody is predicted to not cross-react with other CASKIN family members.
- POSITIVE CONTROL 1: Cat. No. 1201 - HeLa Cell Lysate
- PREDICTED MOLECULAR WEIGHT: Predicted: 157 kDa
Observed: 160 kDa
Properties
- PURIFICATION: CASKIN1 Antibody is affinity chromatography purified via peptide column.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: CASKIN1 Antibody is supplied in PBS containing 0.02% sodium azide.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: CASKIN1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: CASKIN1
- ADDITIONAL NAMES: CASKIN1 Antibody: ANKS5A, KIAA1306, Caskin-1, CASK-interacting protein 1
- Protein Accession Number: NP_065815
- PROTEIN GI NUMBER: 18079216
- NCBI GENE ID NUMBER: 57524
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- CASKIN1 Antibody: Calcium/calmodulin-dependent serine protein kinase (CASK) is a conserved multi-domain scaffolding protein involved in brain development, synapse formation, and establishment of cell polarity. CASKINs (CASK interacting proteins) interact with CASK and is thought to play a role in CASK function, specifically by coupling CASK to distinct downstream effectors. CASKIN1 is a multidomain protein containing six N-terminal ankyrin repeats, one SH3 domain, and two sterile alpha motif domains followed by a long proline-rich sequence and a short conserved C-terminal domain. CASKIN1 coassembles with CASK on the cytoplasmic tail of neurexin 1, suggesting that CASKIN and CASK coat the cytoplasmic tails of neurexins and other cell-surface proteins.
- 1: Stafford RL, Ear J, Knight MJ, et al. The molecular basis of the Caskin1 and Mint1 interaction with CASK. J. Mol. Biol. 2011; 412:3-13.
- 2: Weng YL, Liu N, DiAntonio A, et al. The cytoplasmic adaptor protein Caskin mediates Lar signal transduction during Drosophila motor axon guidance. Neurosci. 2011; 31:4421-33.
- 3: Tabuchi K, Biederer T, Butz S, et al. CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with CASKIN1, a novel CASK-binding protein. J. Neurosci. 2002; 22:4264-73.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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