Specifications
- SPECIES: Human
- SOURCE SPECIES: E. coli
- RECOMBINANT PROTEIN SEQUENCE: aa. 18-417
- TESTED APPLICATIONS: E, MS, WB
- APPLICATION NOTE: This recombinant protein can be used for WB, ELISA, MS.
- PREDICTED MOLECULAR WEIGHT: 46 kDa (Calculated)
Properties
- PURITY: ~90%
- PHYSICAL STATE: Liquid
- BUFFER: 10 mM Tris, pH 8.0, 0.002% NaN3, 3mM NaCl, 2.5mM
- STORAGE CONDITIONS: Store in working aliquots at -70°C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Additional Info
- NCBI OFFICIAL SYMBOL: CALR
- ADDITIONAL NAMES: RO, CRT, SSA, cC1qR, HEL-S-99n, CRTC, Calreticulin, CRP55, ERp60
- Protein Accession Number: NP_004334
- PROTEIN GI NUMBER: 4757900
- NCBI GENE ID NUMBER: 811
Background
- Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium.
- 1: Horibe,T., Matsui,H., Tanaka,M., Nagai,H., Yamaguchi,Y., Kato,K. and Kikuchi,M. Gentamicin binds to the lectin site of calreticulin and inhibits its chaperone activity Biochem. Biophys. Res. Commun. 323 (1), 281-287 (2004)
Disclaimer
- FOR RESEARCH USE ONLY
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