CAD Antibody
CATALOG NUMBER: 55-636- Clonality: Polyclonal
- Tested Applications: Flow, IHC-P, WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Mouse
- IMMUNOGEN: This CAD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 780-809 amino acids from the Central region of human CAD.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: Flow, IHC-P, WB
- APPLICATION NOTE: For FACS starting dilution is: 1:25
For IHC-P starting dilution is: 1:25
For WB starting dilution is: 1:2000 - PREDICTED MOLECULAR WEIGHT: 243 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: CAD
- ADDITIONAL NAMES: CAD protein, Glutamine-dependent carbamoyl-phosphate synthase, Aspartate carbamoyltransferase, Dihydroorotase, CAD
- Protein Accession Number: P27708
- PROTEIN GI NUMBER: 50403731
- NCBI GENE ID NUMBER: 790
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- The de novo synthesis of pyrimidine nucleotides isrequired for mammalian cells to proliferate. This gene encodes atrifunctional protein which is associated with the enzymaticactivities of the first 3 enzymes in the 6-step pathway ofpyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II),aspartate transcarbamoylase, and dihydroorotase. This protein isregulated by the mitogen-activated protein kinase (MAPK) cascade,which indicates a direct link between activation of the MAPKcascade and de novo biosynthesis of pyrimidine nucleotides.
- 1: Jia, P., et al. Schizophr. Res. 122 (1-3), 38-42 (2010) :
- 2: Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- 3: Ahuja, V., et al. J. Inherit. Metab. Dis. 31(4):481-491(2008)
- 4: Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
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