Bone proteoglycan II Recombinant Protein
CATALOG NUMBER: 96-234- Tested Applications: WB
- Size: 0.2 mg
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- SPECIES: Human
- SOURCE SPECIES: HEK293 cells
- RECOMBINANT PROTEIN SEQUENCE: Gly 17 - Lys 359
- FUSION TAG: His Tag
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: This recombinant protein can be used for WB. For research use only.
- PREDICTED MOLECULAR WEIGHT: 38.8 kDa
- BIOLOGICAL ACTIVITY: Measured by its ability to modulate collagen fibrillogenesis. At 5 μg/mL, rhDecorin can significantly delay the rate of type I collagen fibrillogenesis.
Properties
- PURITY: >90% as determined by SDS-PAGE.
Endotoxin level is less than 1.0 EU per ug by the LAL method. - PHYSICAL STATE: Lyophilized
- BUFFER: PBS, pH7.4
- STORAGE CONDITIONS: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Additional Info
- NCBI OFFICIAL SYMBOL: DCN
- ADDITIONAL NAMES: Decorin, DCN, CSCD, DSPG2, PG40, PGII, PGS2, SLRR1B
- Protein Accession Number: NP_001911.1
- NCBI GENE ID NUMBER: 1634
Background
- Decorin is also known as bone proteoglycan II, PGS2, SLRR1B, DCN, DSPG2 and PG40, is a secreted chondroitin /dermatan sulfate proteoglycan in the family of small leucine-rich proteoglycans (SLRPs). Decorin is a small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. Decorin and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. Decorin appears to influence fibrillogenesis, and also interacts with fibronectin, thrombospondin, the complement component C1q, epidermal growth factor receptor (EGFR) and transforming growth factor-beta (TGF-beta). Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD).
- 1: Santra, Manoranjan, et al., 2002, J. Biol. Chem. (United States) 277 (38): 35671–81.
- 2: Iozzo, R V., et al., 1999, J. Biol. Chem. (UNITED STATES) 274 (8): 4489–92.
- 3: Schönherr, E., et al., 1998, Arch. Biochem. Biophys. (UNITED STATES) 355 (2): 241–8.
- 4: Takeuchi, Y., et al., 1994, J. Biol. Chem. (UNITED STATES) 269 (51): 32634–8.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
Shipping Info
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