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Boceprevir
Boceprevir

Boceprevir

CATALOG NUMBER: 11-075
  • Size: 50 mg

Specifications

  • PREDICTED MOLECULAR WEIGHT: 519.7
  • Formula: C27H45N5O5
  • CAS: 394730-60-0
  • Solubility: Soluble in DMSO (15mg/ml), ethanol (20mg/ml) or DMF (20mg/ml).
  • InChi Key: LHHCSNFAOIFYRV-DOVBMPENSA-N
  • Smiles: [H][C@]1(C2(C)C)[C@]2([H])CN(C([C@H](C(C)(C)C)NC(NC(C)(C)C)=O)=O)[C@]1([H])C(NC(CC3CCC3)C(C(N)=O)=O)=O
  • Identity: Determined by 1H-NMR.

Properties

  • PURITY: greater than or equal to 95% (NMR)
  • PHYSICAL STATE: Lyophilized
  • STORAGE CONDITIONS: Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.

Additional Info

  • ADDITIONAL NAMES: Victrelis; EBP 520; SCH 503034

Background

  • The antiviral agent boceprevir is a protease inhibitor that covalently and reversibly binds to the catalytic site (Ser139) of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A), a serine protease that is essential for viral replication (Ki = 14nM) by cleaving the virally encoded polyprotein into mature proteins like NS4A, NS4B, NS5A and NS5B. It inhibits the NS3/4A protease in an in vitro HCV replicon system with an EC50 value of 200 nM.Boceprevir has been identified as a potential inhibitor of SARS-CoV-2 responsible for COVID-19. It inhibits SARS-CoV-2 viral replication by targeting the viral main protease Mpro (IC50 = 4.13µM).

Disclaimer

  • FOR RESEARCH USE ONLY
    For additional information, visit ProSci's Terms & Conditions Page.
  • Disclaimer: This product is for research use only.

CATALOG NUMBER: 11-075

  • Size: 50 mg
  • List Price: $275.00
Datasheet
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