Specifications
- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Non-Human Primate, Rat
- IMMUNOGEN: A synthetic peptide surrounding amino acid S186.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: E, IHC, WB
- APPLICATION NOTE: ELISA, Western (immuno) blotting, Immunostaining (in testing)
Properties
- PURIFICATION: Affinity Purified
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- CONCENTRATION: batch dependent
Additional Info
- NCBI OFFICIAL SYMBOL: BLM
- ADDITIONAL NAMES: Bloom Syndrome Protein pS186 phospho specific, BS, RECQ2, RECQL2, RECQL3
- Protein Accession Number: AAI15031
- PROTEIN GI NUMBER: 1705486
- NCBI GENE ID NUMBER: 641
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- The Bloom syndrome gene product is a member of the RecQ helicase protein family. The protein contains 1417 amino acids; including one ATP binding site, one DEAH box, and two putative nuclear localization signals, as well as phosphorylation sites. BLS protein is known to associate and be phosphorylated by the ATR (ataxia telangiectasia, rad3+) protein, in response to genetic stress. The Bloom's syndrome gene product is thought to play a role in the etiology of two major human health problems, each of which is a very common complication of Bloom's syndrome, namely cancer and diabetes.
- 1: Nathan A. Ellis, Joanna Groden,,Tian-Zhang Ye, Joel Straughen, David J. Lennon, Susan Ciocci , Maria Proytcheva and James German The Bloom's syndrome gene product is homologous to RecQ helicases. Cell, (1994) Vol. 83, 655-668
- 2: Davies SL, North PS, Dart A, Lakin ND, Hickson ID.,Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest. Mol Cell Biol. (2004) Feb;24(3):1279-91
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: This product is for research use only.
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