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Beta III Tubulin Antibody [AA10]Beta III Tubulin Antibody [AA10]
Beta III Tubulin Antibody [AA10]
Beta III Tubulin Antibody [AA10]

Beta III Tubulin Antibody [AA10]

CATALOG NUMBER: 50-261
  • Clonality: Monoclonal
  • Tested Applications: IHC, WB
  • Host Species: Mouse
  • Species Reactivity: Mammal
  • Conjugate: Unconjugated
  • Size: 0.1 mL

Specifications

  • HOST SPECIES: Mouse
  • SPECIES REACTIVITY: Mammal
  • IMMUNOGEN: Synthetic peptide corresponding to beta III tubulin.
  • CONJUGATE: Unconjugated
  • TESTED APPLICATIONS: IHC, WB
  • SPECIFICITY: Specific for the ~55kDa beta III tubulin protein. This clone is similar to the monoclonal antibody Tuj1.
  • PREDICTED MOLECULAR WEIGHT: 55

Properties

  • PURIFICATION: Protein G purified
  • CLONALITY: Monoclonal
  • ISOTYPE: IgG
  • PHYSICAL STATE: Liquid
  • CONCENTRATION: batch dependent
  • STORAGE CONDITIONS: Beta III Tubulin antibody can be stored at -20°C and is stable at -20°C for at least 1 year.

Additional Info

  • NCBI OFFICIAL SYMBOL: Tubb3
  • Protein Accession Number: Q4QRB4
  • PROTEIN GI NUMBER: 81918226
  • NCBI GENE ID NUMBER: 246118
  • USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background

  • Tubulin is the major constituent of microtubules, existing as a heterodimer of the alpha and beta subunits. The beta III isoform of tubulin is found almost exclusively in neuronal processes of adult tissues and is therefore an excellent marker for neurons. Neuron specific, posttranslational modifications within the C-terminal domain of beta III tubulin have been shown to be developmentally regulated suggesting that they may serve to modulate the interaction of tubulin with microtubule associated proteins (Lee et al., 1990). Additionally, beta III tubulin has been found to be highly expressed in cancer cells such as small cell lung cancer, large cell neuroendocrine carcinoma and adenocarcinomas and is correlated with an increasing histological degree of malignancy (Katsetos et al., 2003)
  • 1: Lee MK, Rebhun LI, Frankfurter A (1990) Posttranslational modification of class III beta tubulin. Proc Natl Acad Sci USA 87(18): 7195-7199.
  • 2: Katsetos CD, Herman MM, Mork SJ (2003) Class III beta tubulin in human development and cancer. Cell Motil Cytoskeleton 55(2):77-96.

Disclaimer

  • FOR RESEARCH USE ONLY
    For additional information, visit ProSci's Terms & Conditions Page.
  • Disclaimer: This product is for research use only.

CATALOG NUMBER: 50-261

  • Size: 0.1 mL
  • List Price: $480.00
Datasheet
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