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- SPECIES: Human, Mouse
- SOURCE SPECIES: HEK293 cells
- RECOMBINANT PROTEIN SEQUENCE: The extracellular domain of human BCMA (aa 2-54) is fused at the C-terminus to the Fc portion of human IgG1.
- FUSION TAG: Fc Tag
- APPLICATION NOTE: This recombinant proteins is for research use only.
- BIOLOGICAL ACTIVITY: Blocks the binding of BAFF and APRIL to their receptors BCMA and TACI, inhibiting BAFF- and APRIL-mediated B cell activation.
Properties
- PURITY: >95% (SDS-PAGE).
Endotoxin level is less than 0.01EU/ μg purified protein (LAL test; Lonza). - PHYSICAL STATE: Lyophilized
- BUFFER: Contains PBS. Reconstitute with 50 μl sterile water.
- CONCENTRATION: 1mg/ml after reconstitution.
- STORAGE CONDITIONS: Stable for at least 6 months after receipt when stored at -20°C.
Additional Info
- NCBI OFFICIAL SYMBOL: TNFRSF17
- ADDITIONAL NAMES: B Cell Maturation Protein, CD269, TNFRSF17
- Protein Accession Number: Q02223
- PROTEIN GI NUMBER: 23238192
- NCBI GENE ID NUMBER: 608
Background
- BCMA is a receptor for BAFF and APRIL. It promotes B cell survival and plays a role in the regulation of humoral immunity. Its downstream signaling is dependent on NF-kappaB and JNK.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.
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