BCL-2 (phospho Ser87) Antibody
CATALOG NUMBER: 79-992- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Conjugate: Unconjugated
- Size: 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Rat
- IMMUNOGEN: BCL-2 (phospho Ser87) antibody was raised against a peptide sequence around phosphorylation site of serine 87 (A-L-S (p)-P-V) derived from Human BCL-2.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: Western Blot: 1:500~1:1000
- SPECIFICITY: The antibody detects endogenous level of BCL-2 only when phosphorylated at serine 87.
- PREDICTED MOLECULAR WEIGHT: 28 kDa
Properties
- PURIFICATION: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: Store antibody at -20°C for up to one year.
Additional Info
- NCBI OFFICIAL SYMBOL: BCL2
- ADDITIONAL NAMES: Apoptosis regulator Bcl-2, BCL2
- Protein Accession Number: NP_000624.2
- PROTEIN GI NUMBER: 72198189
- NCBI GENE ID NUMBER: 596
Background
- Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
- 1: Nencioni L, et al. (2009)J Biol Chem 284, 16004-15. Pattingre S, et al. (2009)J Biol Chem 284, 2719-28. Wei Y, et al. (2008)Mol Cell 30, 678-88.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
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