- KO
BAX Antibody, KO Validated
CATALOG NUMBER: 14-223- Clonality: Polyclonal
- Tested Applications: IHC, IP, WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Conjugate: Unconjugated
- Size: 50 uL
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Rat
- IMMUNOGEN: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human BAX (NP_620116.1).
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: IHC, IP, WB
- APPLICATION NOTE: WB: 1:500 - 1:2000
IHC: 1:100 - 1:200
IP: 1:50 - 1:200 - POSITIVE CONTROL 1: 293T
- POSITIVE CONTROL 2: HeLa
- POSITIVE CONTROL 3: Raji
- POSITIVE CONTROL 4: RAW264.7
- POSITIVE CONTROL 5: Mouse lung
- POSITIVE CONTROL 6: Rat lung
- PREDICTED MOLECULAR WEIGHT: Observed: 20kDa
Advanced Validation
- VALIDATION: Antibody is Knockout validated.
Properties
- PURIFICATION: Affinity purification
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at -20°C. Avoid freeze / thaw cycles.
Additional Info
- NCBI OFFICIAL SYMBOL: BAX
- ADDITIONAL NAMES: Bax Antibody: BCL2L4, BCL2L4, Apoptosis regulator BAX, Bcl-2-like protein 4, Bcl2-L-4
- NCBI GENE ID NUMBER: 581
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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$35 Dry Ice Shipment fee may be required on some items.
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