- SPECIES: Human, Mouse
- SOURCE SPECIES: HEK293 cells
- RECOMBINANT PROTEIN SEQUENCE: Mouse BAFF (aa 127-309) is fused at the N-terminus to a DDDDK-tag.
- FUSION TAG: DDDDK Tag
- APPLICATION NOTE: This recombinant proteins is for research use only.
- PURITY: >95% (SDS-PAGE).
Endotoxin level is less than 0.01EU/ μg purified protein (LAL test; Lonza).
- PHYSICAL STATE: Lyophilized
- BUFFER: Contains PBS. Reconstitute with 100 μl sterile water.
- CONCENTRATION: 0.1mg/ml after reconstitution.
- STORAGE CONDITIONS: Stable for at least 6 months after receipt when stored at -20°C.
- NCBI OFFICIAL SYMBOL: Tnfsf13b
- ADDITIONAL NAMES: Tumor Necrosis Factor Ligand Superfamily Member 13B, TNFSF13B, B Cell Activating Factor, CD257
- Protein Accession Number: Q9WU72
- PROTEIN GI NUMBER: 13124571
- NCBI GENE ID NUMBER: 24099
- BAFF is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells. T cells, activated B cells, some malignant B cells and also non-lymphoid cells like astrocytes, synoviocytes and epithelial cells can also produce BAFF. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of BAFF leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases such as Sjoegren syndrome, Rheumatoid arthritis (RA), Multiple sclerosis (MS) and Systemic Lupus Erythematosus (SLE). BAFF has also increased levels in some lymphoid cancers.
- FOR RESEARCH USE ONLY
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- Disclaimer: Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
CATALOG NUMBER: 90-233
- Size: 10 ug
- List Price: $295.00
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