BAD (phospho Ser91/128) Antibody
CATALOG NUMBER: 79-807- Clonality: Polyclonal
- Tested Applications: IHC, WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Conjugate: Unconjugated
- Size: 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Rat
- IMMUNOGEN: BAD (phospho Ser91/128) antibody was raised against a peptide sequence around phosphorylation site of Serine 91 (E-P-S (p)-P-F) derived from Human BAD or Serine 128 (E-P-S (p)-P-F) derived from Mouse BAD.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: IHC, WB
- APPLICATION NOTE: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
- SPECIFICITY: The antibody detects endogenous levels of BAD only when phosphorylated at serine 91/ serine 128.
- PREDICTED MOLECULAR WEIGHT: 22 kDa
Properties
- PURIFICATION: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: Store antibody at -20°C for up to one year.
Additional Info
- NCBI OFFICIAL SYMBOL: BAD
- ADDITIONAL NAMES: BAD, BBC6, BCL2L8, Bcl- XL/Bcl-2 associated death promoter
- Protein Accession Number: NP_004313.1
- PROTEIN GI NUMBER: 10835069
- NCBI GENE ID NUMBER: 572
Background
- The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
- 1: Wang H.-G., Cell 87:629-638(1996).
- 2: Ottilie S., J. Biol. Chem. 272:30866-30872(1997).
- 3: The MGC Project Team, Genome Res. 14:2121-2127(2004).
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
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