- SPECIES: Human
- SOURCE SPECIES: HEK293 cells
- RECOMBINANT PROTEIN SEQUENCE: Phe 33 - Ala 194
- FUSION TAG: Mouse IgG Fc Tag
- TESTED APPLICATIONS: E, WB
- APPLICATION NOTE: This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 45.0 kDa. The protein migrates as 55-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- PREDICTED MOLECULAR WEIGHT: 45.0 kDa
- PURITY: >95% as determined by SDS-PAGE.
- PHYSICAL STATE: Lyophilized
- BUFFER: 50 mM Tris, 100 mM Glycine, pH7.5
- STORAGE CONDITIONS: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
- NCBI OFFICIAL SYMBOL: VSIR
- ADDITIONAL NAMES: B7-H5,SISP1,Gi24,VISTA
- Protein Accession Number: AAH20568.1
- NCBI GENE ID NUMBER: 64115
- Platelet receptor Gi24, also known as B7-H5 and stress-induced secreted protein-1 (Sisp-1), is a protein that in humans is encoded by the C10orf54 gene, which contains 1 Ig-like (immunoglobulin-like) domain. As for C10orf54 gene, C10orf54 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state on ESCs. Human C10orf54 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment.
- 1: Sakr M.A., et al., 2010, Cancer Sci. 101:2368-2374.
- 2: Mayya V., et al ., 2009, Sci. Signal. 2:RA46-RA46.
- FOR RESEARCH USE ONLY
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CATALOG NUMBER: 11-516
- Size: 0.1 mg
- List Price: $455.00
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