ARNT2 Antibody
CATALOG NUMBER: 58-559- Clonality: Polyclonal
- Tested Applications: IF, WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Mouse, Rat
- IMMUNOGEN: This ARNT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 249-278 amino acids from the Central region of human ARNT2.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: IF, WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
For IF starting dilution is: 1:10~50 - PREDICTED MOLECULAR WEIGHT: 79 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: ARNT2
- ADDITIONAL NAMES: Aryl hydrocarbon receptor nuclear translocator 2, ARNT protein 2, Class E basic helix-loop-helix protein 1, bHLHe1, ARNT2, BHLHE1, KIAA0307
- Protein Accession Number: Q9HBZ2
- PROTEIN GI NUMBER: 125987793
- NCBI GENE ID NUMBER: 9915
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- This gene encodes a member of thebasic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily oftranscription factors. The encoded protein acts as a partner forseveral sensor proteins of the bHLH-PAS family, formingheterodimers with the sensor proteins that bind regulatory DNAsequences in genes responsive to developmental and environmentalstimuli. Under hypoxic conditions, the encoded protein complexeswith hypoxia-inducible factor 1alpha in the nucleus and thiscomplex binds to hypoxia-responsive elements in enhancers andpromoters of oxygen-responsive genes. A highly similar protein inmouse forms functional complexes with both aryl hydrocarbonreceptors and Single-minded proteins, suggesting addition roles forthe encoded protein in the metabolism of xenobiotic compounds andthe regulation of neurogenesis, respectively.
- 1: Ramirez, J.M., et al. Eur. J. Immunol. 40(9):2450-2459(2010)
- 2: Jugessur, A., et al. PLoS ONE(7), E11493 (2010) :
- 3: Chakrabarti, B., et al. Autism Res 2(3):157-177(2009)
- 4: Ferreira, M.A., et al. Nat. Genet. 40(9):1056-1058(2008)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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