Specifications
- SPECIES: Human
- SOURCE SPECIES: HEK293 cells
- RECOMBINANT PROTEIN SEQUENCE: Ala 105 - Leu 250
- FUSION TAG: Fc Tag
- TESTED APPLICATIONS: E, WB
- APPLICATION NOTE: This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 42.8 kDa. The protein migrates as 48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- PREDICTED MOLECULAR WEIGHT: 42.8 kDa
Properties
- PURITY: >95% as determined by SDS-PAGE.
- PHYSICAL STATE: Lyophilized
- BUFFER: Tris with Glycine, Arginine and NaCl, pH7.5
- STORAGE CONDITIONS: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Additional Info
- NCBI OFFICIAL SYMBOL: TNFSF13
- ADDITIONAL NAMES: APRIL,TNFSF13,TALL-2,TRDL-1,CD256,TALL2,ZTNF2
- Protein Accession Number: NP_003799.1
- NCBI GENE ID NUMBER: 8741
Background
- APRIL(a proliferation-inducing ligand) is also known as Tumor necrosis factor ligand superfamily member 13, TALL-2, TRDL-1, CD256, TNFFSF 13, cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. APRIL is a cytokine of the tumor necrosis factor family associated mainly with hematologic malignancies. The closely related TNF family ligands B cell activation factor (BAFF) and a proliferation-inducing ligand (APRIL) serve in the generation and maintenance of mature B-lymphocytes. Both BAFF and APRIL assemble as homotrimers that bind and activate several receptors that they partially share. BAFF-APRIL heteromers of different stoichiometries have distinct receptor-binding properties and activities. In addition, expression of APRIL was regulated by miR-145 in GC cells.
- 1: García-Castro A, et al. 2015, Carcinogenesis., 36(5):574-84.
- 2: Schuepbach-Mallepell S, et al. 2015, J Biol Chem., 290(26):16330-42.
- 3: Zhi X, et al. 2015, Cell Physiol Biochem, 35(2):571-85.
Disclaimer
- FOR RESEARCH USE ONLY
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