APLNR Antibody
CATALOG NUMBER: 57-494- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Mouse, Rat
- IMMUNOGEN: This APLNR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-244 amino acids from the Central region of human APLNR.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 43 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: APLNR
- ADDITIONAL NAMES: Apelin receptor, Angiotensin receptor-like 1, G-protein coupled receptor APJ, G-protein coupled receptor HG11, APLNR, AGTRL1, APJ
- Protein Accession Number: P35414
- PROTEIN GI NUMBER: 543823
- NCBI GENE ID NUMBER: 187
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- This gene encodes a member of the G protein-coupledreceptor gene family. The encoded protein is related to theangiotensin receptor, but is actually an apelin receptor thatinhibits adenylate cyclase activity and plays a counter-regulatoryrole against the pressure action of angiotensin II by exertinghypertensive effect. It functions in the cardiovascular and centralnervous systems, in glucose metabolism, in embryonic and tumorangiogenesis and as a human immunodeficiency virus (HIV-1)coreceptor. Two transcript variants resulting from alternativesplicing have been identified.
- 1: Tao, Y., et al. Invest. Ophthalmol. Vis. Sci. 51(8):4237-4242(2010)
- 2: Zhao, Q., et al. Am. J. Hypertens. 23(6):606-613(2010)
- 3: Lee, D.K., et al. Biochem. Biophys. Res. Commun. 395(2):185-189(2010)
- 4: Falcao-Pires, I., et al. Expert Opin. Ther. Targets 14(3):231-241(2010)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
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