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- SPECIES: Human
- SOURCE SPECIES: E. coli
- RECOMBINANT PROTEIN SEQUENCE: Recombinant human annexin V fused to a GST-tag.
- FUSION TAG: GST tag
- APPLICATION NOTE: This recombinant proteins is for research use only.
Properties
- PURITY: >95% (SDS-PAGE)
- PHYSICAL STATE: Liquid
- BUFFER: In PBS, pH 7.4, containing 0.02% sodium azide.
- STORAGE CONDITIONS: Stable for at least 1 year after receipt when stored at +4°C.
Additional Info
- NCBI OFFICIAL SYMBOL: ANXA5
- ADDITIONAL NAMES: Annexin A5, Endonexin II, Lipocortin V, Placental Anticoagulant Protein I, Calphobindin I, Vascular Anticoagulant-alpha
- Protein Accession Number: P08758
- PROTEIN GI NUMBER: 113960
- NCBI GENE ID NUMBER: 308
Background
- Annexin V is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Annexin V competes for phosphatidylserine binding sites (e. g. platelets) with prothrombin or coagulation factors and inhibis the activity of phospholipase A1. Antibodies directed against annexin V are found in patients with a disease called the antiphospholipid syndrome(APS), a thrombophilic disease associated with autoantibodies against phospholipid compounds. Annexin V is used as a probe in the "annexin V affinity assay" to detect cells that have expressed phosphatidylserine on the cell surface, a feature found in apoptosis and other forms of cell death.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
Shipping Info
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$35 Dry Ice Shipment fee may be required on some items.
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