AKTIP Antibody
CATALOG NUMBER: 60-501- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Chicken, Monkey, Mouse, Rat
- IMMUNOGEN: This AKTIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-288 amino acids from the C-terminal region of human AKTIP.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 33 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: AKTIP
- ADDITIONAL NAMES: AKT-interacting protein, Ft1, Fused toes protein homolog, AKTIP, FTS
- Protein Accession Number: Q9H8T0
- PROTEIN GI NUMBER: 54035954
- NCBI GENE ID NUMBER: 64400
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- The mouse homolog of this gene produces fused toes andthymic hyperplasia in heterozygous mutant animals while homozygousmutants die in early development. This gene may play a role inapoptosis as these morphological abnormalities are caused byaltered patterns of programmed cell death. The protein encoded bythis gene is similar to the ubiquitin ligase domain of otherubiquitin-conjugating enzymes but lacks the conserved cysteineresidue that enables those enzymes to conjugate ubiquitin to thetarget protein. This protein interacts directly withserine/threonine kinase protein kinase B (PKB)/Akt and modulatesPKB activity by enhancing the phosphorylation of PKB's regulatorysites. Alternative splicing results in two transcript variantsencoding the same protein.
- 1: Notaridou, M., et al. Int. J. Cancer (2010) In press :
- 2: Quaye, L., et al. Hum. Mol. Genet. 18(10):1869-1878(2009)
- 3: Xu, L., et al. Mol. Biol. Cell 19(12):5059-5071(2008)
- 4: Lamesch, P., et al. Genomics 89(3):307-315(2007)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
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