- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Rat
- IMMUNOGEN: A specific peptide of human Acetyl-TP53-K370
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: IF, IP, WB
- APPLICATION NOTE: WB: 1:500 - 1:2000
IF: 1:50 - 1:200
IP: 1:20 - 1:50
- POSITIVE CONTROL 1: HepG2 treated with Etoposide and Trichostatin
- POSITIVE CONTROL 2: Untreated
- PREDICTED MOLECULAR WEIGHT: Observed: 53kDa
- PURIFICATION: Affinity purification
- CLONALITY: Monoclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
- STORAGE CONDITIONS: Store at -20°C. Avoid freeze / thaw cycles.
- NCBI OFFICIAL SYMBOL: TP53 K370ac
- ADDITIONAL NAMES: TP53, P53, BCC7, LFS1, TRP53
- NCBI GENE ID NUMBER: 7157
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
- This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).
- FOR RESEARCH USE ONLY
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- Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
CATALOG NUMBER: 13-883
- Size: 50 uL
- List Price: $335.00
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