ABCD2 Antibody
CATALOG NUMBER: 56-546- Clonality: Polyclonal
- Tested Applications: Flow, IHC-P, WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- IMMUNOGEN: This ABCD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 553-582 amino acids from the C-terminal region of human ABCD2.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: Flow, IHC-P, WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50 - PREDICTED MOLECULAR WEIGHT: 83 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: ABCD2
- ADDITIONAL NAMES: ATP-binding cassette sub-family D member 2, Adrenoleukodystrophy-like 1, Adrenoleukodystrophy-related protein, hALDR, ABCD2, ALD1, ALDL1, ALDR, ALDRP
- Protein Accession Number: Q9UBJ2
- PROTEIN GI NUMBER: 12643305
- NCBI GENE ID NUMBER: 225
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- The protein encoded by this gene is a member of thesuperfamily of ATP-binding cassette (ABC) transporters. ABCproteins transport various molecules across extra- andintra-cellular membranes. ABC genes are divided into seven distinctsubfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). Thisprotein is a member of the ALD subfamily, which is involved inperoxisomal import of fatty acids and/or fatty acyl-CoAs in theorganelle. All known peroxisomal ABC transporters are halftransporters which require a partner half transporter molecule toform a functional homodimeric or heterodimeric transporter. Thefunction of this peroxisomal membrane protein is unknown; howeverthis protein is speculated to function as a dimerization partner ofABCD1 and/or other peroxisomal ABC transporters. Mutations in thisgene have been observed in patients with adrenoleukodystrophy, asevere demyelinating disease. This gene has been identified as acandidate for a modifier gene, accounting for the extreme variationamong adrenoleukodystrophy phenotypes. This gene is also acandidate for a complement group of Zellweger syndrome, agenetically heterogeneous disorder of peroxisomal biogenesis.
- 1: Matsukawa, T., et al. Neurogenetics (2010) In press :
- 2: Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)
- 3: Maier, E.M., et al. Biochem. Biophys. Res. Commun. 377(1):176-180(2008)
- 4: Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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