- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- IMMUNOGEN: 4E-BP1 (phospho Thr70) antibody was raised against a peptide sequence around phosphorylation site of threonine70 (T-K-T (p)-P-P) derived from Human 4E-BP1.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: IHC
- SPECIFICITY: The antibody detects endogenous levels of 4E-BP1 only when phosphorylated at threonine 70.
- PREDICTED MOLECULAR WEIGHT: 12 kDa
- PURIFICATION: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: Store antibody at -20°C for up to one year.
- NCBI OFFICIAL SYMBOL: EIF4EBP1
- ADDITIONAL NAMES: 4EBP1, P/OKCL.6, P/OKCL.6, PHAS-I
- Protein Accession Number: NP_004086.1
- PROTEIN GI NUMBER: 4758258
- NCBI GENE ID NUMBER: 1978
- 4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
- 1: Pause A., Nature 371:762-767(1994).
- 2: Gevaert K., Nat. Biotechnol. 21:566-569(2003).
- 3: Haghighat A., EMBO J. 14:5701-5709(1995).
- FOR RESEARCH USE ONLY
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- Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
CATALOG NUMBER: 79-891
- Size: 0.1 mg
- List Price: $335.00
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