4E BP1 (Ab 36) Antibody
CATALOG NUMBER: 79-367- Clonality: Polyclonal
- Tested Applications: IHC, WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Conjugate: Unconjugated
- Size: 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Rat
- IMMUNOGEN: 4E-BP1 (Ab-36) antibody was raised against a peptide sequence around aa.34~38 (S-T-T-P-G) derived from Human 4E-BP1.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: IHC, WB
- APPLICATION NOTE: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
- SPECIFICITY: This antibody detects endogenous level of total 4E-BP1 protein.
- PREDICTED MOLECULAR WEIGHT: 18 kDa
Properties
- PURIFICATION: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- CLONALITY: Polyclonal
- PHYSICAL STATE: Liquid
- BUFFER: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: Store antibody at -20°C for up to one year.
Additional Info
- NCBI OFFICIAL SYMBOL: EIF4EBP1
- ADDITIONAL NAMES: BP-1, 4EBP1, 4E-BP1, PHAS-I, Trp6, Trrp6, EIF4EBP1, PHAS-1
- Protein Accession Number: NP_004086.1
- PROTEIN GI NUMBER: 4758258
- NCBI GENE ID NUMBER: 1978
Background
- 4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
- 1: Gingras AC, et al. Genes Dev Nov. 2005 Feb 15. Mothe-Satney I, et al. (2000) J Biol Chem:15 (21): 2852-64. Gingras AC, et al. (1999) Genes Dev:13 (11): 1422-37. Lal L, et al. (2005) Blood;105 (4): 1669-7.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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