PRKAB1 Antibody [1F9G6] Cat. No.: 13-300

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psi-iconSpecifications
HOST SPECIES:Mouse
SPECIES REACTIVITY: Human, Monkey, Mouse, Rat
IMMUNOGEN: Recombinant protein of human PRKAB1
TESTED APPLICATIONS: ICC, IHC, IP, WB
APPLICATIONS: WB: ,1:500 - 1:2000

IHC: ,1:50 - 1:200

ICC: ,1:20 - 1:50

IP: ,1:50 - 1:200
POSITIVE CONTROL:1) HeLa
 2) PC-12
 3) SH-SY5Y
 4) NCI-H460
 5) Jurkat
 6) NIH/3T3
PREDICTED MOLECULAR WEIGHT: Observed: 38kDa

psi-iconProperties
PURIFICATION:Affinity purification
CLONALITY:Monoclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
STORAGE CONDITIONS:Store at -20˚C. Avoid freeze / thaw cycles.

psi-iconAdditional Info
OFFICIAL SYMBOL:PRKAB1
ALTERNATE NAMES:PRKAB1, AMPK beta 1, AMPK subunit beta-1, AMPKb, AMPK, AMPK beta -1 chain, HAMPKb
GENE ID:5564
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.

ANTIBODIES FOR RESEARCH USE ONLY.

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