PPARA Antibody Cat. No.: 49-503

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Boar, Bovine, Dog, Hamster, Human, Mouse, Rat
IMMUNOGEN: PPARA antibody was raised against amino acids 25 - 42 of PPARA (Mouse).
TESTED APPLICATIONS: ELISA, IHC, WB
APPLICATIONS: PPARA antibody can be used in ELISA, Western Blot starting at 1 μg/mL, and immunohistochemistry starting at 5 μg/mL.

psi-iconProperties
PURIFICATION:Immunoaffinity Chromatography
CLONALITY:Polyclonal
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:Short term: 4˚C. Long term: Store at -20˚C. Avoid freeze-thaw cycles.

psi-iconAdditional Info
OFFICIAL SYMBOL:PPARA
ALTERNATE NAMES:PPARA, PPAR Alpha, PPARalpha, PPAR-alpha, NR1C1, HPPAR, PPAR
ACCESSION NO.:Q07869
PROTEIN GI NO.:3041727
GENE ID:5465
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Since their discovery in the early 1990's, the peroxisome proliferator activated receptors (PPARs) have attracted significant attention. This is primarily because PPARs serve as receptors for two very important classes of drugs: the hypolipidemic fibrates and the insulin sensitizing thiazolidinediones. Peroxisome proliferators are non-genotoxic carcinogens that are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed PPARs. Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Upon binding fatty acids or hypolipidemic drugs, PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate the expression of target genes. There are 3 known subtypes of PPARs: PPAR-alpha, PPAR-delta and PPAR-gamma. Mostly target genes are involved in the catabolism of fatty acids. Conversely, PPAR-gamma is activated by peroxisome proliferators such as prostaglandins, leukotrienes and anti-diabetic thiazolidinediones and affects the expression of genes involved in the storage of the fatty acids. PPAR-gamma may also be involved in adipocyte differentiation. It has also been shown that PPARs can induce transcription of acyl coenzyme A oxidase and cytochrome P450 through interaction with specific response elements.

ANTIBODIES FOR RESEARCH USE ONLY.

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