Potassium Channel Antibody Cat. No.: XPS-2027

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Rat, Xenopus
IMMUNOGEN: Potassium Channel, Kv2.
TESTED APPLICATIONS: IHC, WB
APPLICATIONS: Potassium Channel antibody can be used for specific immunolabeling of the ~125k Kv 2.2 protein in Western blots. Applications include Dot Blots (DB), Immunohistochemistry (IHC) and Western Blots (WB). Rabbit anti-Potassium Channel, Kv2.2 recognizes Kv2.2 in rat and Xenopus. When internally tested under ideal conditions the working dilutions were 1:1000 for IHC, DB and WB.
PREDICTED MOLECULAR WEIGHT: 100

psi-iconProperties
PURIFICATION:Affinity Purified
CLONALITY:Polyclonal
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.
STORAGE CONDITIONS:Potassium Channel, Kv2.2 Subunit antibody can be stored at -20˚C. After reconstitution in 50 μl PBS, the antibody should be aliquot and stored at -20˚C and is stable at -20˚C for at least 1 year. Ambient shipment is suitable for both international and domestic.

psi-iconAdditional Info
OFFICIAL SYMBOL:Kcnb2
ALTERNATE NAMES:Kv2.2, CDRK,
ACCESSION NO.:Q63099
PROTEIN GI NO.:24418850
GENE ID:117105
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Voltage-gated K+ channels are important determinants of neuronal membrane excitability, and differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. The delayed rectifier-type (IK)channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety on non-neuronal cells types including pancreatic islets, alveolar cells and cardiac myocytes. Kv2.1 and Kv2.2 form distinct populations of K+ channels and these subunits are thought to be primarily responsible for IK in superior cervical ganglion cells.
REFERENCES:1) Burger, C. and Ribera, A.B. "Xenopus spinal neurons express Kv2 potassium channel transcripts during embryonic development," J Neurosci. 16 (1996) 1412 - 1421.
2) Pongs, O. "Voltage-gated potassium channels: from hyperexcitability to excitement," FEBS Lett. 452 (1999) 31-35.
3) Maletic-Savatic, M., Lenn, N.J., and Trimmer, J.S. "Differential spatiotemporal expression of K+ channel polypeptides in rat hippocampal neurons developing in situ and in vitro," J Neurosci. 15 (1995) 3840-3851.
4) Hwang, P.M., Fotuhi, M., Bredt, D.S., Cunningham, A.M., and Snyder, S.H. "Contrasting immunohistochemical localizations in rat brain of two novel K+ channels of the Shab subfamily," J. Neurosci., 13 (1993) 1569 - 1576.

ANTIBODIES FOR RESEARCH USE ONLY.

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