Specifications
| HOST SPECIES: | Rabbit |
| SPECIES REACTIVITY: |
Human |
| IMMUNOGEN: |
This PLZF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 637-666 amino acids from the C-terminal region of human PLZF. |
| TESTED APPLICATIONS: |
WB |
| APPLICATIONS: |
For WB starting dilution is: 1:1000 |
| PREDICTED MOLECULAR WEIGHT: |
74 kDa |
Properties
| PURIFICATION: | This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis |
| CLONALITY: | Polyclonal |
| ISOTYPE: | Rabbit Ig |
| CONJUGATE: | Unconjugated |
| PHYSICAL STATE: | Liquid |
| BUFFER: | Supplied in PBS with 0.09% (W/V) sodium azide. |
| CONCENTRATION: | batch dependent |
| STORAGE CONDITIONS: | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Additional Info
| OFFICIAL SYMBOL: | ZBTB16 |
| ALTERNATE NAMES: | Zinc finger and BTB domain-containing protein 16, Promyelocytic leukemia zinc finger protein, Zinc finger protein 145, Zinc finger protein PLZF, ZBTB16, PLZF, ZNF145 |
| ACCESSION NO.: | Q05516 |
| PROTEIN GI NO.: | 90109930 |
| GENE ID: | 7704 |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
Background and References
| BACKGROUND: | PLZF is a member of the Krueppel C2H2-type zinc-finger protein family and a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). |
| REFERENCES: | 1) Shi,J., Int. J. Cancer 125 (7), 1558-1565 (2009) |
| 2) Doulatov,S., Genes Dev. 23 (17), 2076-2087 (2009) |
ANTIBODIES FOR RESEARCH USE ONLY.
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