PD1 Detection Set Cat. No.: SD8600

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psi-iconSpecifications
SPECIES REACTIVITY:Human
TESTED APPLICATIONS:ELISA
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
IMMUNOGEN:PD-1 antibodies were raised against a recombinant protein corresponding to amino acids 25 - 167 of human PD-1.
HOST SPECIES:Llama
psi-iconSet Contents
Catalog Number SD8643Catalog number SD8643 — PD-1 Antibody [F12A8]
Catalog Number SD8645Catalog number SD8645 — PD-1 Antibody [F42D7]
Catalog Number SD8647Catalog number SD8647 — PD-1 Antibody [F34C9]
Catalog Number SD8649Catalog number SD8649 — PD-1 Antibody [F25F4]
psi-iconProperties
PHYSICAL STATE:Liquid
BUFFER:PD-1 Antibodies are supplied in PBS.
CONCENTRATION:Antibody 1 mg/mL
STORAGE CONDITIONS:PD-1 antibodies should be stored in working aliquots at -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Monoclonal
ISOTYPE:sdab
CONJUGATE:Unconjugated
psi-iconAdditional Info
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground
BACKGROUND:PD-1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases.

DETECTION-SETS FOR RESEARCH USE ONLY.

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