PD-L1 Antibody [F2G2] Cat. No.: SD8641

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psi-iconSpecifications
HOST SPECIES:Llama
SPECIES REACTIVITY: Human
IMMUNOGEN: PD-L1 antibody was raised against a recombinant protein corresponding to amino acids 19 - 239 of human PD-L1.
TESTED APPLICATIONS: ELISA, ICC, IF
APPLICATIONS: PD-L1 antibody can be used for detection of PD-L1 by ELISA, Immunocytochemistry (10 μg/ml) and immunofluorescence (20 μg/ml).
SPECIFICITY: At least three isoforms of PD-L1 are known to exist.

psi-iconProperties
PURIFICATION:PD-L1 Antibody is affinity chromatography purified via Nickel column. Antibody is supplied as a His-tagged purified protein.  It also contains a myc-tag for detection.
CLONALITY:Monoclonal
ISOTYPE:sdAb
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:PD-L1 Antibody is supplied in PBS.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:PD-L1 antibody should be stored in working aliquots at -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:CD274
ALTERNATE NAMES:PD-L1 Antibody: B7-H, B7H1, PDL1, PD-L1, PDCD1L1, PDCD1LG1, Programmed cell death 1 ligand 1, B7 homolog 1
ACCESSION NO.:NP_054862
PROTEIN GI NO.:7661534
GENE ID:29126
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:PD-L1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts.
REFERENCES:1) Holling TM, Schooten E, and van Den Elsing PJ. Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. Hum. Immunol. 2004; 65:282-90.
2) Ishida Y, Agata Y, Shibahara K, et al. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 1992; 11:3887-95.
3) LaGier J and Pober JS. Immune accessory functions of human endothelial cells are modulated by overexpression of B7-H1 (PDL1). Hum. Immunol. 2006; 67:568-78.

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