PCDHA4 Antibody Cat. No.: 58-269

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human
IMMUNOGEN: This PCDHA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 761-790 amino acids from the C-terminal region of human PCDHA4.
TESTED APPLICATIONS: WB
APPLICATIONS: For WB starting dilution is: 1:1000
PREDICTED MOLECULAR WEIGHT: 102 kDa

psi-iconProperties
PURIFICATION:This antibody is purified through a protein A column, followed by peptide affinity purification.
CLONALITY:Polyclonal
ISOTYPE:Rabbit Ig
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Supplied in PBS with 0.09% (W/V) sodium azide.
CONCENTRATION:batch dependent
STORAGE CONDITIONS:Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:PCDHA4
ALTERNATE NAMES:Protocadherin alpha-4, PCDH-alpha-4, PCDHA4
ACCESSION NO.:Q9UN74
PROTEIN GI NO.:13878424
GENE ID:56144
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
REFERENCES:1) Wu, Q., et al. Genome Res. 11(3):389-404(2001)
2) Nollet, F., et al. J. Mol. Biol. 299(3):551-572(2000)
3) Yagi, T., et al. Genes Dev. 14(10):1169-1180(2000)
4) Wu, Q., et al. Proc. Natl. Acad. Sci. U.S.A. 97(7):3124-3129(2000)

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